STREPTOMYCIN AND DIHYDROSTREPTOMYCIN

The status of streptomycin and dihydrostreptomycin in the treatment of leprosy.

Deafness in tuberculous meningitis with a comparison between streptomycin, (calcium chloride complex) and dihydrostreptomycin.

The successful clinical results obtained with dihydrostreptomycin in clinical and experimental tuberculosis and its comparative lack of neurotoxicity as reported by Edison et al. (1948), Feldman et al. (I948), Hinshaw et al. (1948) and Hobson et al. (I948) led to the general introduction of this drug into the therapy of tuberculosis. We have been using this drug since I949, but in concert with ...

The effects of salts on streptomycin and dihydrostreptomycin in agar plate assays.

Experiments on the effects of salt on streptomycin in agar plate assays have produced confficting observations. According to a recent paper by Berkman, Henry, and Housewright (1947), "the inclusion of 2.0 per cent sodium chloride, potassium chloride, or ammonium acetate and 0.85 per cent sodium chloride or ammonium acetate to the streptomycin sulfate solutions prepared for assay in 0.1 M phosph...

[3H] dihydrostreptomycin accumulation and binding to ribosomes in Rhizobium mutants with different levels of streptomycin resistance.

Rhizobium trifolii B1, a symbiotic nitrogen fixer, is sensitive to streptomycin (10 microgram/ml) and spontaneously produces spheroplast-like forms during cultivation. Streptomycin-resistant mutants selected with high doses of antibiotic (1,000 microgram/ml) showed pleiotropic changes, including loss of spheroplast formation and infectivity to plants, whereas mutants selected with low doses of ...

Intracellular distribution of 3H-dihydrostreptomycin in a streptomycin-dependent strain of Bacillus megaterium.

The cells of a streptomycin-dependent strain of Bacillus megaterium took up only 2 to 5% of the dihydrostreptomycin present in the medium when grown in the minimum concentration of streptomycin required for growth. During growth in the presence of (3)H-dihydrostreptomycin, radioactivity was accumulated intracellularly in three forms, namely, unbound, loosely bound to the ribosomes (removable by...